You're searching for faculty members in:
Neurosurgery
14 matches found.
 | Paul Bernstein
Neurosurgery
| | | Ming Cheng
Neurosurgery
| | | Deus Cielo
Neurosurgery
| | | Curtis Doberstein
Neurosurgery
| | | Mel Epstein
Neurosurgery
| | | Samuel Greenblatt
Neurosurgery
Neuroscience, Department of
Writing an 'intellectual biography' of the English neurologist, John Hughlings Jackson (1835-1911). He (and Charcot in France) set the paradigm for neurological thinking to the present time. I believe he also influenced our fundamental thought patterns in basic neuroscience/neurophysiology through his indirect but strong influence on Sherrington and other British neuroscientists in the 20th century. If we could understand the assumptions in this paradigm, could we do the current science better? |  | Richard Alan Haas
Diagnostic Imaging
Neurosurgery
|  | Conrad Johanson
Neurosurgery
Molecular Pharmacology, Physiology and Biotechnology, Department of
Professor of Clinical Neuroscience (Neurosurgery) Conrad Johanson investigates the transport and permeability roles of the blood-Cerebrospinal Fluid (CSF) interface (choroid plexus) and blood-brain barrier (cerebral capillaries) in regulating the neuronal fluid environment. His research involves models of ischemia, hydrocephalus, and aging to clarify how CSF and brain interstitial fluid homeostatic mechanisms are altered in Alzheimer's disease. The goal is to identify pharmacological strategies for preventing or repairing damage to 'barrier cells' that defend the integrity of brain fluids. |  | Arthur Messier
Neurosurgery
As we, as a society, are living longer we need to ensure that we address the medical problems unique to this age group. Alzheimer's disease(AD) is our area of study. We are looking at an animal model of AD to investigate the physiology and molecular biological changes in an aged rat model. By determining the role of the specialized blood brain barrier (tissue lining the blood vessels of the brain) and the fluid surronding the brain (cerebral spinal fluid), we hope to provide insight into the mechanism(s) leading to the symptomology of this debilitating disease. | | | Adetokunbo Oyelese
Neurosurgery
| | | N. Stevenson Potter
Neurology
Neurosurgery
|  | Gerald Silverberg
Neurosurgery
My research goals are to determine the effects of aging on the pathways of amyloid removal (clearance) from the brain. The accumulation of amyloid, a sticky protein composed of amyloid-beta peptides (Aβ), appears to be the cause of Alzheimer’s disease (AD). Age is the primary risk factor for developing AD, so it is critical to assess the effects of aging on clearance of Aβ from the extra cellular fluid space (ISF) of the brain. Clearance of Aβ from the brain occurs via two major pathways: the cerebrospinal fluid (CSF) circulation and transport from the ISF into the blood stream directly across the brain capillaries. There are two transporters known that affect Aβ concentration in the ISF. The low density lipoprotein-related protein-1 (LRP-1) transports Aβ out of the ISF and into the plasma. The receptor for advanced glycated end-products (RAGE) transports Aβ from the plasma into the ISF. We postulate that age-related changes in the CSF circulation and in the BBB account for the inability to clear Aβ from the brain in aging and in the age-related dementias. We are examining these age-related changes in a model of aging provided by the Brown-Norway rat, an animal now available at 10, 20 and 30+ months of age, corresponding to early adult, middle age and aged in humans. Measurement of CSF production and CSF volume will yield the turnover rate of CSF at each age group. Studies of the choroid plexus, the main site of CSF production, as a function of aging will help determine the cause of diminished CSF turnover. Imunostaining of Aβ, LRP-1 and RAGE along with RT-PCR and Western blotting will determine if aging affects the expression of these receptors on the capillary endothelium and if these changes correlate with amyloid deposition. | | | Julius Stoll
Neurosurgery
| | | Bradford Thompson
Neurology
Neurosurgery
Dr. Thompson's research interests include outcomes analyses in patients suffering from a wide variety of neurocritical care diseases, including intracerebral hemorrhage, subarachnoid hemorrhage, and traumatic brain injury. |
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