 | Mary Ambler
Pathology and Laboratory Medicine, Department of
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| | Barbara Barker
Pathology and Laboratory Medicine, Department of
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| | William Bastan
Pathology and Laboratory Medicine, Department of
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 | Elaine Bearer
Pathology and Laboratory Medicine, Department of
Living cells are dynamic—transporting components inside, changing their shape, and locomoting. In the central nervous system, this dynamic behavior establishes, maintains and modifies neuronal connections. We use a range of microscopic imaging and molecular techniques to understand the mechanisms of these dynamics using model systems, including squid giant axon, transport of Herpes simplex virus, and human blood platelets. These studies address fundamental questions pertaining to learning and memory.
I also direct a medical clerkship in Guatemala, and hold an appointment as a composer in the Music Department. Please see the links below my photo for more information. |
 | Kim Boekelheide
Pathology and Laboratory Medicine, Department of
In our laboratory, we use many basic techniques in biochemistry and molecular and cell biology to investigate interdisciplinary problems in reproductive toxicology/biology. A major issue in environmental health is mixed exposures. We are using prototypal cell-type specific testicular toxicants to dissect interactions and inter-dependencies among those cells responsible for successful spermatogenesis. Ongoing experiments evaluate the potential roles of local paracrine growth and death factors in the regulation of spermatogenesis following injury. Knockout and transgenic mice are used to investigate these growth and death factor pathways. |
| | Linda Bradley
Pathology and Laboratory Medicine, Department of
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| | Julia Brody
Pathology and Laboratory Medicine, Department of
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| | Jacob Canick
Pathology and Laboratory Medicine, Department of
Beginning in the 1980s, our laboratory has studied secretory products of the human fetus and placenta as possible screening markers for prenatal identification of serious birth defects. We have been able to convert our findings into clinically important prenatal screening tests, now used throughout the world. In particular, our research has focused on prenatal screening markers and tests for fetal Down syndrome, trisomy 18, and various complications of pregnancy. |
 | Esteban Cardemil
Pathology and Laboratory Medicine, Department of
Dr. Cardemil's research focuses on understanding and addressing the mental healthcare disparities that continue to disproportionately affect individuals from low-income and racial/ethnic minority backgrounds. Research projects include the development and evaluation of effective depression prevention programs for low-income minorities, questionnaire-based research that examines how sociocultural context influences depression, and mixed-methods investigations of the help-seeking process. |
| | James Carlsten
Pathology and Laboratory Medicine, Department of
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| | Kimberle Chapin
Pathology and Laboratory Medicine, Department of
Medicine, Department of
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| | Suzanne DeLaMonte
Pathology and Laboratory Medicine, Department of
We study the roles of brain insulin deficiency and insulin resistance in neurodegeneration. Three diseases of major interest to us are: Alzheimer's, alcoholic neurodegeneration, and fetal alcohol syndrome. Experimentally, we examine how insulin deficiency and/or insulin resistance leads to neuronal death, reduced energy metabolism, and decreased neurotransmission. We also investigate therapeutic measures to prevent or reverse brain abnormalities caused by insulin resistance (Type 3 diabetes). |
| | Monique DePaepe
Pathology and Laboratory Medicine, Department of
Our research focuses on the regulation of alveolar remodeling in normal and pathological lung development. We are particularly interested in deciphering the role and regulation of apoptosis (programmed cell death) and angiogenesis (microvascular development) in alveolarization. We anticipate that these studies will contribute to the development of novel therapeutic strategies for bronchopulmonary dysplasia, a chronic lung disease of preterm infants characterized by arrested alveolar development. |
 | Ronald Delellis
Pathology and Laboratory Medicine, Department of
The research interests of Dr. Ronald DeLellis are in:
• The biology of thyroid cancer;
• Multiple endocrine neoplasia syndromes/clinical and molecular features;
• Immunohistochemical and in situ hybridization methodologies/applications in surgical pathology and cytopathology. |
 | John E. Donahue
Pathology and Laboratory Medicine, Department of
Neurology
While there is a growing body of evidence to indicate that the blood-brain barrier (BBB) is compromised in Alzheimer's disease (AD), there has been little data to support a link between known risk factors for AD and the BBB. My research will attempt to show that the product of the ε4 allele of the APOE gene, a known risk factor for developing AD, somehow fails to maintain the integrity of the BBB, compared to the ε3 allele, and that this BBB failure leads to the chain of events resulting in AD. |
| | Luba Dumenco
Pathology and Laboratory Medicine, Department of
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| | Jacob Dyckman
Pathology and Laboratory Medicine, Department of
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| | Alfredo Esparza
Pathology and Laboratory Medicine, Department of
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| | Ronald Faris
Pediatrics, Department of
Pathology and Laboratory Medicine, Department of
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| | Nelson Fausto
Pathology and Laboratory Medicine, Department of
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| | A. Raymond Frackelton
Medicine, Department of
Pathology and Laboratory Medicine, Department of
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| | Thomas Gilson
Pathology and Laboratory Medicine, Department of
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| | Douglas Gnepp
Pathology and Laboratory Medicine, Department of
Applied surgical pathology of the head and neck and salivary glands. |
| | Lisa Goldstein
Pathology and Laboratory Medicine, Department of
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| | Rogers Griffith
Pathology and Laboratory Medicine, Department of
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| | Antonio Gualberto
Pathology and Laboratory Medicine, Department of
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| | Fusun Gundogan
Pathology and Laboratory Medicine, Department of
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| | Volkan Gurel
Pathology and Laboratory Medicine, Department of
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| | James Haddow
Pathology and Laboratory Medicine, Department of
Dr. Haddow's interests focus on translating clinical research into practice, specifically in the areas of medical screening and public health. Beginning in 1974, his work led to the introduction of the first statewide screening program for detecting neural tube defects prenatally. This expanded to include detection of Down syndrome in 1985, along with several other serious medical disorders. In 1999, he reported a landmark study on maternal thyroid deficiency during pregnancy and its effects on the baby's brain. His recent interests include screening adults for serious medical problems, such as hereditary breast cancer and thyroid insufficiency. |
| | L. Corey Hanley
Pathology and Laboratory Medicine, Department of
Currently investigating alcohol effects on pregnancy. I am looking at differences between pregnancies influenced by maternal alcohol consumption and pregnancies where there is no maternal alcohol exposure. |
| | Katrine Hansen
Pathology and Laboratory Medicine, Department of
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| | James Harper
Pathology and Laboratory Medicine, Department of
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| | Mai He
Pathology and Laboratory Medicine, Department of
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| | Judith Heelan
Pathology and Laboratory Medicine, Department of
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 | Mary Hixon
Pathology and Laboratory Medicine, Department of
Reproductive toxicants are ubiquitous in our modern day environment. The major focus of our research is directed at understanding the molecular signaling pathways responsible for germ cell survival in the male and female reproductive system. Ionizing radiation, phthalates, and thyroid toxicants are areas of current research interest in our laboratory. |
| | Qin Huang
Pathology and Laboratory Medicine, Department of
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 | Cynthia Jackson
Pathology and Laboratory Medicine, Department of
Several clinically important diseases and tumor-associated genetic alterations have been linked to human chromosome 9p. We are focusing our research on two different diseases whose causative genes are located on 9p. We are interested in identifying the mechanism by which mutations in the gene RMRP, RNA component of the mitochondrial RNA processing gene, cause the genetic disease cartilage-hair hypoplasia. |
| | Russell Jacobs
Pathology and Laboratory Medicine, Department of
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 | Agnes Kane
Pathology and Laboratory Medicine, Department of
My research focuses on the potential health effects of environmental and occupational exposure to asbestos fibers,metallic nanoparticles, and carbon nanomaterials. My laboratory has also developed a murine model of asbestos induced malignant mesothelioma that reproduces the morphologic and molecular characteristics of the human disease. This murine model will be used to develop new strategies for prevention and treatment of asbestos-related cancer. |
| | Karl Kelsey
Community Health, Department of
Pathology and Laboratory Medicine, Department of
Center for Environmental Health and Technology
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| | Noubar Kessimian
Pathology and Laboratory Medicine, Department of
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| | Jila Khorsand
Pathology and Laboratory Medicine, Department of
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| | Michael Klein
Pathology and Laboratory Medicine, Department of
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| | George Knight
Pathology and Laboratory Medicine, Department of
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 | Stefan Kostadinov
Pathology and Laboratory Medicine, Department of
My research interests are primarily in the field of perinatal pathology and reproductive immunology. I am currently working on a project that will study the type of immune responses involved in the ability of the embryo to implant and develop successfully.
In addition, I am collaborating in the Stillbirth Collaborative Research Network (SCRN), a multi institutional study which will attempt to elucidate the epidemiology and etiology of stillbirth. |
| | Nicola Kouttab
Pathology and Laboratory Medicine, Department of
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 | Jonathan Kurtis
Pathology and Laboratory Medicine, Department of
Dr. Jonathan Kurtis applies the techniques of molecular biology, immunology and population biology to identify vaccine candidates for both malaria and schistosomiasis in east Africa and the Philippines. By analyzing the relationship between specific immune responses and naturally acquired resistance in endemic populations, Dr. Kurtis identifies and characterizes new vaccine candidates. His current interests include the modulation of protective immune responses by nutritional and developmental factors in the human host and the identification of vaccine candidates for pediatric falciparum malaria. |
| | Elizabeth Laposata
Pathology and Laboratory Medicine, Department of
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| | Syed Latif
Pathology and Laboratory Medicine, Department of
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| | Dorota Latuszynski
Pathology and Laboratory Medicine, Department of
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| | W. Dwayne Lawrence
Pathology and Laboratory Medicine, Department of
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| | N. Peter Libbey
Pathology and Laboratory Medicine, Department of
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| | Michele Lomme
Pathology and Laboratory Medicine, Department of
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| | Abby Maizel
Pathology and Laboratory Medicine, Department of
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| | Shamlal Mangray
Pathology and Laboratory Medicine, Department of
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 | Carmen Marsit
Pathology and Laboratory Medicine, Department of
My research is focused on understanding the role that exposures and lifestyle play in determining the character of the human epigenome. This highly interdisciplinary and collaborative work, relying on both laboratory biology as well as epidemiology and biostatistics, examines molecular alterations in human tissues and correlates these alterations to various epidemiologic and clinical measures to better understand the mechanisms by which exposures lead to pathologies. |
| | Paul McMillan
Pathology and Laboratory Medicine, Department of
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| | Geralyn M. Messerlian
Pathology and Laboratory Medicine, Department of
The focus of my research is the role of the inhibin and activin family in fertility, pregnancy, ovarian cancer, and fetal development. |
| | Jeffrey Moffit
Pathology and Laboratory Medicine, Department of
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| | David Morris
Pathology and Laboratory Medicine, Department of
My research is focused on the mechanisms of action of mineralocorticoids and glucocorticoids, not only in the kidney, but also in vascular tissue, with particular attention on their effects relating to sodium retention and hypertension. In addition, we plan to measure the levels of endogenous inhibitors in diseases including essential hypertension, obesity, and ocular hypertension. |
| | Jayasimha Murthy
Pathology and Laboratory Medicine, Department of
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 | Calvin Oyer
Pathology and Laboratory Medicine, Department of
Study of cardiovascular anomalies in fetuses and neonates. Correlation of autopsy findings with fetal or postnatal echocardiography. Establishment of reference values for valve measurements and ventricular wall thicknesses based on 25 year autopsy records at Women and Infants' Hospital.Use of knowledge thus gained in presentations at conferences with medical students, residents, fellows, and attendings in pediatrics, obstetrics, and pediatric cardiology. |
| | Glenn Palomaki
Pathology and Laboratory Medicine, Department of
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 | M. Halit Pinar
Pathology and Laboratory Medicine, Department of
The National Institute of Child Health and Human Development (NICHD), a branch of the National Institutes of Health (NIH) established the Stillbirth Collaborative Research Network (SCRN) in 2003 to understand the epidemiology and etiology of stillbirth. Brown University is one of the five academic centers that form this network. Dr. Pinar is the Co-Principal Investigator and Lead Perinatal Pathologist responsible for the implementation of standardized postmortem and placental examinations. |
| | Latha Pisharodi
Pathology and Laboratory Medicine, Department of
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| | M. Ruhul Quddus
Pathology and Laboratory Medicine, Department of
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 | Murray Resnick
Pathology and Laboratory Medicine, Department of
1) Analysis of novel diagnostic and prognostic markers in gastrointestinal malignancies using tissue microarray technology;
2) Identification of novel proteins involved in Helicobacter pylori pathogenesis and gastric tumorogenesis;
3) Computerized morphometry in experimental pathology. |
| | Abdalla Rifai
Pathology and Laboratory Medicine, Department of
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 | Sharon Rounds
Medicine, Department of
Pathology and Laboratory Medicine, Department of
Sharon Rounds is interested in mechanisms of lung vascular injury in conditions causing pulmonary hypertension and acute lung injury. Her work focuses on the way in which endothelial cells of the lung circulation are injured. Current research focuses on the role of small GTPase post-translational processing in modulation of lung vascular permeability and apoptosis.
She is also interested in chronic obstructive pulmonary disease and factors that impair compliance with therapy. Another clinical research interest is pulmonary hypertension. |
| | Ruthann Rudel
Pathology and Laboratory Medicine, Department of
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 | Edmond Sabo
Pathology and Laboratory Medicine, Department of
Our research aims to better understand the pathogenesis of Barrett's esophagus (BE) and to find prognostic predictors of disease progression. The methods we use are: 1) Computerized morphometry (image analysis) of microscopic images obtained from BE biopsies; 2) Bioinformatics: data mining of gene microarrays and protein profiles of the epithelial cells in BE biopsies; 3) Statistical and NNET analysis to correlate between the profiles (gene, protein, morphometric) and the clinical outcomes. |
| | Stanley Schwartz
Pathology and Laboratory Medicine, Department of
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| | Michael Sheff
Pathology and Laboratory Medicine, Department of
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| | David Shrayer
Pathology and Laboratory Medicine, Department of
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| | Rochelle Simon
Pathology and Laboratory Medicine, Department of
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| | Don Singer
Pathology and Laboratory Medicine, Department of
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| | Darius Stachurski
Pathology and Laboratory Medicine, Department of
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| | Janusz Starakiewicz
Pathology and Laboratory Medicine, Department of
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| | Margaret Steinhoff
Pathology and Laboratory Medicine, Department of
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 | Edward Stopa
Pathology and Laboratory Medicine, Department of
Alzheimer's disease (AD) is generally regarded as a degenerative disease, but many normal physiological processes are increased in AD patients. My research deals with proteins involved in three major physiological processes in the brain: cell growth and differentiation; maintaining the environment between neurons (the extra-cellular matrix); and the inflammatory response. The question is whether these proteins and physiological processes play a critical role in initiating the disease or whether they are increased as a result of the disease. |
| | C. James Sung
Pathology and Laboratory Medicine, Department of
My research interests are in gynecological pathology, breast pathology, and cytopathology, particularly in tumor pathology of these areas. |
| | Joseph Sweeney
Medicine, Department of
Pathology and Laboratory Medicine, Department of
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| | Akiko Takeda
Pathology and Laboratory Medicine, Department of
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| | Umadevi Tantravahi
Pathology and Laboratory Medicine, Department of
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 | Nancy Thompson
Pathology and Laboratory Medicine, Department of
Medicine, Department of
Administration
Nancy L. Thompson, Ph.D., is Associate Dean for Graduate and Postdoctoral Studies in the Division of Biology & Medicine at Brown University, Professor of Medicine and Pathology & Laboratory Medicine (Research). Previous active research interests included cancer/injury related gene expression and molecular biomarkers. Dr. Thompson has been the PI of 2 Department of Education GAANN pre-doctoral training grants and is currently Co-PI of an Initiative to Maximize Student Development grant from NIH. |
| | Diana Treaba
Pathology and Laboratory Medicine, Department of
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 | Herman Vandenburgh
Pathology and Laboratory Medicine, Department of
Autologous adult human skeletal muscle cells have numerous potential cell transplantation applications, including regenerating heart and skeletal muscle, and for therapeutic protein delivery when genetically engineered to express a recombinant protein. Our research examines the survival and functionality of human muscle cells transplanted in vivo for the development of improved methods for the treatment of numerous endocrine, neuromuscular, and cardiovascular disorders. |
| | Charles Vaslet
Pathology and Laboratory Medicine, Department of
Dr. Vaslet applies his expertise in molecular pathology to explore genetic alterations in the development of asbestos-induced cancer. He applies the tools of biotechnology to assess the potential toxicity of newly-developed nanomaterials. |
| | Annette Von Dem Bussche
Pathology and Laboratory Medicine, Department of
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| | Lijuan Wang
Pathology and Laboratory Medicine, Department of
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| | Evgeny Yakirevich
Pathology and Laboratory Medicine, Department of
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| | Carolyn Te Young
Pathology and Laboratory Medicine, Department of
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| | Cunxian Zhang
Pathology and Laboratory Medicine, Department of
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 | Anatoly Zhitkovich
Pathology and Laboratory Medicine, Department of
Our main research efforts are directed at characterization of molecular mechanisms responsible for cell death and mutagenicity of DNA-reactive carcinogenic chemicals and anticancer drugs. |
